Rendering shown. Your prescription arrives in Parke's unmarked, temperature-controlled packaging. Compounded medications are not FDA-approved.
MIC + B12 RX
A once-weekly injection that pairs methylcobalamin, the active form of B12, with methionine, inositol, and choline. Prescribed by the clinician who reviews your intake, and followed for as long as you're in care.
- Methylcobalamin B12 plus three lipotropic compounds, one weekly dose
- Injected, so it bypasses digestion entirely
- Free discreet delivery, monthly or quarterly
- Unlimited clinician messaging between refills
Multi-month plans show the average monthly cost and are billed upfront. Your final plan and price are set with your clinician, and you can pause or cancel anytime.
Four compounds.
One considered protocol.
MIC + B12 pairs the active form of vitamin B12 with three lipotropic compounds your body already uses in everyday metabolism.
Essential amino acid
One of the building blocks of protein, and a player in how the liver processes fat. Your body can't make it, so it has to come from outside.
Cellular messenger
A sugar-like compound involved in cell signaling and how your body responds to insulin. Part of the machinery, not a stimulant.
Essential nutrient
Needed to move fat out of the liver and to build the membranes every cell is wrapped in. Most adults don't reach the recommended daily intake.
Active form of B12
Central to energy metabolism, red-blood-cell production, and nerve health. Injected, it doesn't depend on your gut to absorb it.
Together, a nutrient-support protocol.
Your clinician decides if it's right for you.
Thirty seconds, once a week.
MIC + B12 is designed to slot into your actual life, not reorganize it.
- One small injection, weekly. Same day each week, about 30 seconds, with guided instructions in your member portal.
- No clinics, no pharmacy lines. Everything ships to your door in unmarked, temperature-controlled packaging.
- A clinician on your side of it. Questions between refills are answered by your care team, usually the same business day.
Built for real life
Prescribed for you, then reviewed.
There's no ramp-up to manage. The decision is whether it's helping, and your clinician keeps asking. This is the typical arc, though yours may differ.
Your starting rhythm
A standard weekly dose, set by your clinician from your intake. Most members pick a day and keep it. The routine matters more than the hour.
Taking stock, honestly
Your clinician checks in on how you feel, any side effects, and whether labs are worth ordering. If it isn't doing anything for you, they'll say so.
Only as long as it's useful
Ongoing treatment is a decision you revisit together, not an auto-renewal. Weekly, every other week, or paused: whichever the evidence in your chart supports.
Every step is reviewed. Refills at Parke are approved by the clinician who knows your chart, never by an auto-renewal system. Adjustments, including spacing doses out or pausing, are included in your plan.
What's established,
what isn't, said plainly.
Adults over 60 with low or marginal B12 status in U.S. population estimates, and roughly 1 in 16 under 60. Deficiency is common, under-recognized, and correctable.
Injectable B12 is a well-established treatment for B12 deficiency. It bypasses the gut, which is why it's the standard approach when absorption is the problem. The lipotropic compounds in MIC (methionine, inositol, and choline) are nutrients your body uses in fat and energy metabolism every day.
We want to be direct: the evidence that MIC injections cause weight loss or “burn fat” is limited and has not been established in rigorous clinical trials. Parke does not prescribe MIC + B12 as a weight-loss treatment, and it is not a substitute for GLP-1 therapy. B12 supplementation helps most when levels are low, and your clinician decides whether that's likely to be you. Compounded MIC + B12 is not FDA-approved or evaluated. Individual results vary and are never guaranteed.
Two reasonable routes. One right answer: yours.
You don't have to choose alone. Your clinician recommends one based on your history and how you respond, and will tell you if a supplement from the pharmacy shelf is the better answer.
On MIC + B12, in their words.
“My labs came back low and nobody had ever mentioned it. The weekly shot is easy, and the three o'clock wall I used to hit just isn't there most days.”
“I asked if it would make me lose weight and the clinician said, honestly, probably not on its own. I trusted the rest of the plan more because of that.”
“Sunday morning, thirty seconds, done. When the first injection stung more than I expected, a real clinician wrote back that afternoon with what to change.”
Individual results and experiences vary. Testimonials reflect the experiences of specific members and are not a guarantee of outcomes. Treatment is prescribed only when a licensed clinician determines it is appropriate.
Side effects, said plainly.
You deserve the whole picture before you start, not after.
Common, usually temporary
- Soreness, redness, or a small bruise at the injection site
- Mild nausea or stomach upset, especially the first few doses
- Headache, or a brief flushed or warm feeling
- Mild diarrhea or changes in appetite
Rare, but serious: call your clinician
- Allergic reaction: hives, facial swelling, trouble breathing
- Injection-site pain or swelling that spreads or won't settle
- Chest pain, palpitations, or sudden shortness of breath
- Numbness, tingling, or unusual muscle weakness
How Parke handles this: your clinician screens your full history before prescribing (including allergies, kidney and liver health, and certain inherited conditions where B12 is not appropriate) and is reachable between refills. Most side-effect questions are answered the same business day, and changes to your schedule are included in every plan. Full details in the important safety information.
Asked, answered, plainly.
Can't find your question? Message us. A human on our care team replies, usually within a few hours.
A once-weekly injection that combines methylcobalamin, the active form of vitamin B12, with three lipotropic compounds: methionine, inositol, and choline. At Parke it's prescribed as a compounded preparation by a licensed clinician, when appropriate, and prepared by state-licensed US pharmacies.
No, and we'd rather say so up front. MIC injections are often marketed that way, but the evidence that they cause weight loss on their own is limited and hasn't held up in rigorous trials. We prescribe MIC + B12 as nutrient support, most often when B12 levels are low or absorption is in question. If weight is your goal, your clinician will talk with you about GLP-1 therapy instead, or alongside.
Oral B12 has to be absorbed through the gut, which depends on stomach acid and a protein called intrinsic factor. Age, certain medications (including common acid reducers and metformin), and some GI conditions can get in the way. An injection bypasses all of that. For people who absorb B12 normally, a good oral supplement often works fine, and your clinician will tell you if that's you.
Often, yes. Many members on semaglutide or tirzepatide add MIC + B12 when their clinician thinks nutrient support is warranted, since reduced food intake on GLP-1 therapy can make that more relevant. Whether to combine, and how to schedule it, is decided inside your existing plan by the clinician who knows your chart.
Eligibility is a clinical decision made from your full intake. MIC + B12 is not prescribed during pregnancy or breastfeeding, with a known allergy to cobalt or cobalamin, with Leber's hereditary optic neuropathy, or with certain kidney or liver conditions, among other factors your clinician reviews before any prescription is written.
Everything: your medication and supplies, clinician reviews, schedule adjustments, unlimited care-team messaging, and free discreet shipping. No membership fees, no hidden charges, no cancellation fees. Lab work, if your clinician recommends it, is discussed with you first.
Anytime, from your member portal, in about two clicks. No contracts, no cancellation fees, no retention phone calls. Multi-month plans can be paused with your remaining shipments held.
Explore other concierge treatments.
Steadier energy, considered properly, starts with a conversation.
A private 2-minute assessment, read by a clinician who will decide with you: MIC + B12, something else, or nothing at all.
No charge unless a clinician approves your plan · Pause or cancel anytime
Important safety information: compounded MIC + B12 (methionine, inositol, choline, methylcobalamin)
Do not use if you are allergic to cobalt, cobalamin (vitamin B12), methionine, inositol, choline, or any component of the preparation, or if you have Leber's hereditary optic neuropathy, which can worsen with cobalamin treatment. Tell your clinician if you are pregnant, breastfeeding, or planning pregnancy; have kidney or liver disease, a history of acidosis, gout, a blood disorder such as polycythemia vera, or a folate deficiency, which should be evaluated and treated alongside B12. Tell your clinician about all medications and supplements, including metformin, acid-reducing medicines, and antibiotics, which can affect B12 status. Common side effects include pain, redness, or bruising at the injection site, mild nausea or stomach upset, headache, and flushing. Rarely, allergic reactions (including hives, swelling of the face or throat, and difficulty breathing) can occur; stop use and seek immediate care if they do. Seek care for spreading injection-site pain, warmth, or swelling, chest pain, palpitations, or new numbness or weakness.
Compounded MIC + B12 is prepared by state-licensed US compounding pharmacies and is not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. Methionine, inositol, and choline have not been shown in rigorous clinical trials to cause weight loss; MIC + B12 is not prescribed or intended by Parke as a weight-loss treatment, and is not a substitute for GLP-1 therapy or for the evaluation of any underlying medical condition. B12 supplementation is most likely to help when levels are low or absorption is impaired; whether that applies to you is a clinical decision made from your intake and, where appropriate, lab work. Population statistics referenced on this page are general estimates of B12 status and do not predict individual results. This page is informational, is not medical advice, and does not guarantee any outcome. If you are experiencing a medical emergency, call 911.