Rendering shown. Your prescription arrives in Parke's unmarked, cold-chain packaging. Compounded medications are not FDA-approved.
Semaglutide RX
The GLP-1 most people start with, and the one with the deepest evidence behind it. A once-weekly injection, titrated by the clinician who reviewed your intake and adjusted for as long as you are in care.
- Once-weekly dosing, titrated slowly and deliberately
- Reviewed by your clinician before every refill
- Free cold-chain delivery, unmarked packaging
- Unlimited clinician messaging between refills
Multi-month plans show the average monthly cost and are billed upfront. Your final plan and price are set with your clinician, and you can pause or cancel anytime.
One hormone.
One very well studied pathway.
Semaglutide copies a hormone your gut already releases after a meal, and lets it act for a week instead of minutes.
Quiets the noise
Semaglutide slows gastric emptying and acts on appetite signaling. Meals feel satisfying sooner, and the constant background chatter about food fades.
Built to last a week
Natural GLP-1 breaks down within minutes. Semaglutide is engineered to resist that, which is what turns a mealtime signal into a once-weekly injection.
One pathway, understood better than any other in this class. Your clinician decides whether it fits you.
Thirty seconds, once a week.
Semaglutide is designed to disappear into your actual life, not reorganize it.
- One small injection, weekly. Same day each week, about 30 seconds, with guided instructions in your member portal.
- No clinics, no pharmacy lines. Everything ships cold-chain to your door in unmarked packaging.
- A clinician on your side of it. Questions between refills are answered by your care team, usually the same business day.
Built for real life
Titrated to you, never rushed.
Your dose is a clinical decision that evolves as your body responds. This is the typical arc, though yours may differ.
An on-ramp, not a treatment dose
The label calls this a starting dose, and it is: its job is introducing your gut to the mechanism. Most early side effects, if any, show up and settle here.
The climb begins
If your first month goes well, your clinician steps you up. Appetite effects often become unmistakable somewhere in the middle rungs, not at the bottom.
Only as far as necessary
Higher rungs exist, and 1.7 mg is a recognized maintenance dose in its own right. The lowest dose that holds your result is the right dose.
Every step is reviewed. Dose changes at Parke are made by the clinician who knows your chart, never by an auto-renewal system. Adjustments, including slowing down or pausing, are included in your plan. New to the word? Titration, explained, in the Journal.
The most studied molecule
in the category.
Average body-weight reduction over 68 weeks in the pivotal trial of branded, FDA-approved semaglutide 2.4 mg, alongside diet and exercise.
In the pivotal 68-week trial of branded semaglutide 2.4 mg, 83.5 percent of adults lost at least 5 percent of body weight, against 31.1 percent on placebo. It is the GLP-1 with the longest track record and the largest body of published evidence behind it, which is why most people start here.
Those results come from trials of FDA-approved branded semaglutide products, not compounded preparations, which are not FDA-approved or evaluated. Compounded semaglutide is not interchangeable with any branded product. Individual results vary with dose, adherence, lifestyle, and history, and are never guaranteed.
Two good options. One right answer: yours.
You don't have to choose alone. Your clinician recommends one based on your history, goals, and how you respond, and can adjust course later. If a switch makes sense later, we wrote the playbook for it.
On semaglutide, in their words.
“I had read about this for two years before I did anything. What I did not expect was a clinician who answered the small questions, not just the prescription.”
“The Sunday-night injection takes less time than making coffee. The food noise going quiet was the part nobody prepared me for.”
“They started me low and never rushed the dose. When week two felt rough, a real doctor answered that afternoon, not a chatbot.”
Individual results and experiences vary. Testimonials reflect the experiences of specific members and are not a guarantee of outcomes. Treatment is prescribed only when a licensed clinician determines it is appropriate.
Side effects, said plainly.
You deserve the whole picture before you start, not after.
Common, usually temporary
- Nausea, especially in the first weeks and after dose increases
- Constipation or diarrhea
- Reduced appetite (that's the mechanism, but it can be abrupt)
- Fatigue or mild injection-site reactions
Rare, but serious: call your clinician
- Severe abdominal pain that doesn't pass (possible pancreatitis)
- Gallbladder symptoms: pain, fever, yellowing skin
- Signs of low blood sugar if you take insulin or sulfonylureas
- Allergic reactions: swelling, trouble breathing
How Parke handles this: your clinician screens your full history before prescribing, starts you at the lowest dose, and is reachable between refills. Most side-effect questions are answered the same business day, and dose adjustments are included in every plan. Full details in the important safety information.
Asked, answered, plainly.
Can't find your question? Message us. A human on our care team replies, usually within a few hours.
Semaglutide is a once-weekly injectable medication that activates the GLP-1 receptor, part of the system your body already uses to signal fullness, slow digestion, and manage blood sugar after meals. It is engineered to last about a week in the body rather than the few minutes natural GLP-1 survives. At Parke it is prescribed as a compounded preparation by a licensed clinician, when appropriate, and prepared by state-licensed US pharmacies.
Semaglutide works on one pathway (GLP-1); tirzepatide works on two (GLP-1 and GIP). In head-to-head trials of the branded, FDA-approved products, tirzepatide produced greater average weight reduction. That does not make it the right first step for everyone: semaglutide has the longer track record, a lower price at Parke, and is where most people begin. Your clinician weighs your history, goals, and tolerance. Our honest head-to-head comparison covers it at length.
Judge it at about 12 weeks, including several settled weeks at a real working dose, not during the 0.25 mg on-ramp, whose job is tolerance rather than results. Appetite changes often arrive before scale changes. If twelve honest weeks at a therapeutic rung show neither, that is a real signal and exactly the message your clinician wants. Our results timeline maps the whole arc.
Eligibility is a clinical decision made from your full intake. Semaglutide is not prescribed during pregnancy or breastfeeding, or with a personal or family history of medullary thyroid carcinoma or MEN 2, among other factors your clinician reviews before any prescription is written. See the full eligibility page.
Everything: your medication, clinician reviews, dose adjustments, unlimited care-team messaging, and free cold-chain shipping. No membership fees, no hidden charges, no cancellation fees.
Message your care team. Clinical questions are usually answered the same business day. Your clinician can slow your titration, hold a dose, or step back a rung, and most early side effects settle as your body adjusts. Our guides to nausea and the full side-effect picture cover what to expect.
Anytime, from your member portal, in about two clicks. No contracts, no cancellation fees, no retention phone calls. Multi-month plans can be paused with your remaining shipments held.
Explore other concierge treatments.
The proven starting point, considered properly, starts with a conversation.
A private 2-minute assessment, read by a clinician who will decide with you: semaglutide, tirzepatide, or neither.
No charge unless a clinician approves your plan · Pause or cancel anytime
Important safety information: compounded semaglutide
Warning: Semaglutide-containing medicines caused thyroid C-cell tumors in rodent studies; it is unknown whether they cause such tumors in humans. Do not use with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or during pregnancy or breastfeeding. The branded label advises discontinuing at least 2 months before a planned pregnancy. Common side effects include nausea, vomiting, diarrhea, constipation, decreased appetite, and abdominal pain. Serious risks include pancreatitis, gallbladder disease, kidney injury, severe gastrointestinal disease, diabetic retinopathy complications, and low blood sugar when combined with insulin or sulfonylureas. Tell your clinician about all medical conditions, including a history of gastroparesis, diabetic retinopathy, or kidney or pancreas problems, and all medications before starting treatment. Stop use and seek immediate care for severe abdominal pain, symptoms of an allergic reaction, or vision changes.
Compounded semaglutide is prepared by state-licensed US compounding pharmacies and is not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. It is not the same as, interchangeable with, or a substitute for any FDA-approved branded semaglutide product. Parke is not affiliated with, endorsed by, or sponsored by the manufacturers of branded semaglutide products; all trademarks belong to their respective owners. Clinical-trial results referenced on this page come from studies of FDA-approved branded products and do not apply to compounded formulations. This page is informational, is not medical advice, and does not guarantee any outcome. If you are experiencing a medical emergency, call 911.