Rendering shown. Your prescription arrives in Parke's unmarked, temperature-controlled packaging. Compounded medications are not FDA-approved.
Sermorelin RX
A nightly peptide injection that asks your pituitary for the growth hormone it already makes. Not growth hormone itself: a signal, with your body's own limits intact, and a clinician who reviews every refill.
- A 30-second bedtime routine, timed to your body's own rhythm
- Works upstream: your own hormone, your own feedback loops
- Free discreet delivery, monthly or quarterly
- Unlimited clinician messaging between refills
Multi-month plans show the average monthly cost and are billed upfront. Your final plan and price are set with your clinician, and you can pause or cancel anytime.
A signal, not a hormone.
Here is what that means.
Sermorelin is not growth hormone. It is a copy of the message your brain already sends when it wants growth hormone released, delivered on your body's own terms.
The active fragment
Sermorelin is a peptide: the first 29 amino acids of growth-hormone-releasing hormone, the piece of the natural hormone that carries its activity.
Asking, not replacing
It signals the pituitary gland to release your own growth hormone. Your body's feedback loops stay in charge of how much, which direct hormone injections bypass.
Output falls with age
Growth hormone secretion declines steadily through adulthood. That decline is well documented; what reversing it does for healthy adults is still being studied.
Why nightly
Your largest natural growth hormone pulse happens early in deep sleep. The injection is timed at bedtime to work with that rhythm rather than against it.
Established physiology, honestly framed.
Your clinician decides whether it fits you.
Thirty seconds, then sleep.
Sermorelin is a bedtime habit, not a project. A small injection before you turn the lights off, and the rest happens while you sleep.
- One small injection, nightly. At bedtime, about 30 seconds, with guided instructions in your member portal.
- A honest word on commitment. This is a nightly protocol, not a weekly one. If a daily routine is not realistic for you right now, your clinician will say so before you spend anything.
- A clinician on your side of it. Questions between refills are answered by your care team, usually the same business day.
Built for real life
A slow axis, judged fairly.
Sermorelin works through a hormonal system that changes over months, not days. The protocol is built around that honesty. Yours may differ.
Learning the habit
One small subcutaneous dose at bedtime, sites rotated. The first week is about the routine, not the results; most people find it takes under a minute by night three.
Giving the axis time
Growth hormone signaling changes slowly. Anything worth noticing tends to arrive gradually across the first months, which is why nobody should judge this in week two.
Only as long as it earns it
At the review you and your clinician decide together, with labs if warranted. If you cannot tell the difference after a fair trial, they will say so rather than keep shipping it.
Every step is reviewed. Refills at Parke are approved by the clinician who knows your chart, never by an auto-renewal system. Adjustments, including lowering your dose or pausing, are included in your plan. New to the word? Titration, explained, in the Journal.
Real physiology,
early adult evidence.
Sermorelin is the working fragment of the hormone your brain already uses to request growth hormone. The signal is borrowed from your own physiology, not invented.
What is well established is the pharmacology: sermorelin stimulates the pituitary to release growth hormone. A branded sermorelin product was FDA-approved on exactly that basis, including as a diagnostic for growth hormone deficiency, before being discontinued in the US for commercial reasons; the FDA later formally determined it was not withdrawn for safety or effectiveness reasons.
What is not established is the adult payoff. The approval history is largely pediatric, and the studies behind adult wellness uses, body composition, sleep quality, recovery, are small, short, and mixed. None support marketing sermorelin as an anti-aging treatment, and Parke does not make that claim. What you receive is a compounded preparation, which is not FDA-approved or evaluated. Individual results vary, many people notice nothing, and nothing here is guaranteed.
Upstream, on purpose.
You don't have to choose alone. Your clinician weighs your history and your goals, and will tell you plainly if sermorelin is not the right place to spend your money.
On sermorelin, in their words.
“The routine took a week to stop feeling strange. Now it is just part of turning the lights off, like brushing my teeth.”
“My clinician told me up front the adult evidence is early and I might notice nothing. I appreciated that more than a promise. Three months in, my mornings feel less like a negotiation.”
“I asked whether this was the same as the stuff bodybuilders take and got a straight, patient answer about what it is and is not. That is why I stayed.”
Individual results and experiences vary. Testimonials reflect the experiences of specific members and are not a guarantee of outcomes. Treatment is prescribed only when a licensed clinician determines it is appropriate.
Side effects, said plainly.
You deserve the whole picture before you start, not after.
Common, usually brief
- Pain, redness, or swelling at the injection site, the most commonly reported effect
- Flushing or a brief feeling of warmth after injecting
- Headache or lightheadedness
- Nausea, or drowsiness beyond the usual bedtime kind
Rare, but serious: call your clinician
- Allergic reaction: hives, facial swelling, trouble breathing
- Chest tightness or a racing heart that does not settle
- Injection-site pain or swelling that spreads or will not settle
- New or unusual symptoms that persist between doses
How Parke handles this: your clinician screens your full history first, including thyroid function, which can blunt the response if untreated, blood sugar, and any history of cancer, because prescribing a growth-signaling peptide responsibly means asking those questions. Sites are rotated, instructions are guided, and your care team is reachable between refills, usually the same business day. Full details in the important safety information.
Asked, answered, plainly.
Can't find your question? Message us. A human on our care team replies, usually within a few hours.
Sermorelin is a synthetic peptide made of the first 29 amino acids of growth-hormone-releasing hormone, the fragment that carries the natural hormone's activity. Injected, it signals your pituitary gland to release your own growth hormone. At Parke it is prescribed as a compounded preparation by a licensed clinician, when appropriate, and prepared by state-licensed US pharmacies.
No, and the difference matters. Direct growth hormone replaces the hormone from outside and bypasses your body's regulation entirely. Sermorelin works upstream: it asks your pituitary to release its own, and your feedback loops still decide how much. That built-in ceiling is the main reason clinicians who work with this axis tend to prefer the signaling approach. It is also not a steroid, and it is nothing like one.
Honestly: possibly nothing, and nothing quickly. Growth hormone signaling changes over months, and the adult evidence for benefits like body composition, sleep quality, or recovery is small, short, and mixed. Some members describe gradual changes across the first months; others notice nothing and stop at the review. Your clinician will set that expectation before you spend anything, and will say so when a fair trial has not worked.
Your largest natural pulse of growth hormone is released early in deep sleep. Dosing sermorelin at bedtime lines the signal up with the rhythm your body already runs, rather than fighting it. Practically, it also makes the habit easy to keep: the injection becomes part of turning in, about thirty seconds before lights out.
A branded sermorelin injection was FDA-approved, principally for diagnosing and treating growth hormone deficiency in children, and was later discontinued in the US for commercial reasons; the FDA subsequently made a formal determination that it was not withdrawn for safety or effectiveness reasons. What Parke prescribes today is a compounded preparation from state-licensed US pharmacies, which, like all compounded medications, is not FDA-approved or evaluated for safety, effectiveness, or quality.
Eligibility is a clinical decision made from your full intake. Sermorelin is not prescribed during pregnancy or breastfeeding, with an active malignancy, with a known sensitivity to any component, and only cautiously alongside untreated thyroid disease or poorly controlled blood sugar, among other factors your clinician reviews before any prescription is written. See the full eligibility page.
Everything: your medication and supplies, clinician reviews, dose adjustments, unlimited care-team messaging, and free discreet shipping. No membership fees, no hidden charges, no cancellation fees.
Anytime, from your member portal, in about two clicks. No contracts, no cancellation fees, no retention phone calls. Multi-month plans can be paused with your remaining shipments held.
Explore other concierge treatments.
A quieter kind of signal, honestly framed, starts with a conversation.
A private 2-minute assessment, read by a clinician who will decide with you: sermorelin, something else, or nothing at all.
No charge unless a clinician approves your plan · Pause or cancel anytime
Important safety information: compounded sermorelin injection
Do not use if you are allergic to sermorelin or any component of the preparation. Tell your clinician if you are pregnant, breastfeeding, or planning pregnancy; have or have had any cancer; have a thyroid condition, since untreated hypothyroidism can reduce the response to sermorelin; have diabetes or trouble controlling blood sugar; have a pituitary or other endocrine condition; or take any medications or supplements, including thyroid hormone, corticosteroids, or insulin. The most commonly reported effects are injection-site reactions: pain, redness, or swelling. Flushing or warmth, headache, dizziness, nausea, and drowsiness have also been reported. Rarely, allergic reactions (including hives, swelling of the face or throat, and difficulty breathing) can occur; stop use and seek immediate care if they do. Seek care for chest tightness, a racing heart that does not settle, or spreading injection-site pain, warmth, or swelling.
Compounded sermorelin is prepared by state-licensed US compounding pharmacies and is not FDA-approved or evaluated by the FDA for safety, effectiveness, or quality. A branded sermorelin product was previously FDA-approved, principally for pediatric growth hormone deficiency, and was discontinued in the US for commercial reasons; the FDA formally determined it was not withdrawn for safety or effectiveness reasons. Sermorelin has not been shown in rigorous adult clinical trials to slow or reverse aging, build muscle, improve sleep or recovery, or treat any adult condition, and Parke does not prescribe or market it for those claims or as a substitute for sleep, nutrition, exercise, or evaluation of any underlying medical condition. This page is informational, is not medical advice, and does not guarantee any outcome. If you are experiencing a medical emergency, call 911.